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3EQG	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQF	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P Descriptor: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, K-252A, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQD	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P Descriptor: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQC	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P Descriptor: 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQB	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Ohren, J.F, Pavlovsky, A, Zhang, E. Deposit date: 2008-09-30 Release date: 2008-11-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.62 Å) Cite: 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). Bioorg.Med.Chem.Lett., 18, 2008
3E8N	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Yan, S, Wang, Z.M. Deposit date: 2008-08-20 Release date: 2009-09-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res., 69, 2009
3DY7	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP Descriptor: (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Ohren, J.F, Pavlovsky, A, Zhang, E. Deposit date: 2008-07-25 Release date: 2009-06-16 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19, 2009
3DV3	MEK1 with PF-04622664 Bound Descriptor: 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(2-hydroxyethoxy)methyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Kazmirski, S.L, Kothe, M, Ding, Y.-H. Deposit date: 2008-07-18 Release date: 2009-07-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19, 2009
3DIK	Pseudo-atomic model of the HIV-1 CA hexameric lattice Descriptor: Capsid protein p24 Authors: Ganser-Pornillos, B.K, Cheng, A, Yeager, M. Deposit date: 2008-06-20 Release date: 2008-09-16 Last modified: 2024-02-21 Method: ELECTRON CRYSTALLOGRAPHY (9 Å) Cite: Structure of full-length HIV-1 CA: a model for the mature capsid lattice Cell(Cambridge,Mass.), 131, 2007
2Z7L	Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid Descriptor: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Katayama, N, Kurihara, H. Deposit date: 2007-08-27 Release date: 2008-08-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors Proteins, 73, 2008
2Y4I	KSR2-MEK1 heterodimer Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, ... Authors: Brennan, D.F, Barford, D. Deposit date: 2011-01-06 Release date: 2011-01-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.46 Å) Cite: A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek Nature, 472, 2011
2XDE	Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal domain Descriptor: GAG POLYPROTEIN, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE Authors: Brown, D.G, Irving, S.L, Anderson, M, Bazin, R. Deposit date: 2010-04-30 Release date: 2010-12-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.4 Å) Cite: HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention. Plos Pathog., 6, 2010
2X2D	acetyl-CypA:HIV-1 N-term capsid domain complex Descriptor: CAPSID PROTEIN P24, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A Authors: Lammers, M, Neumann, H, Chin, J.W, James, L.C. Deposit date: 2010-01-12 Release date: 2010-03-23 Last modified: 2018-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Acetylation Regulates Cyclophilin a Catalysis, Immunosuppression and HIV Isomerisation Nat.Chem.Biol., 6, 2010
2WLV	Structure of the N-terminal capsid domain of HIV-2 Descriptor: GAG POLYPROTEIN Authors: Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C. Deposit date: 2009-06-26 Release date: 2009-09-22 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp Nat.Struct.Mol.Biol., 16, 2009
2PXR	Crystal Structure of HIV-1 CA146 in the Presence of CAP-1 Descriptor: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol), ZINC ION Authors: Kelly, B.N. Deposit date: 2007-05-14 Release date: 2007-09-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWO	Crystal Structure of HIV-1 CA146 A92E Psuedo Cell Descriptor: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol) Authors: Kelly, B.N. Deposit date: 2007-05-11 Release date: 2007-09-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWM	Crystal Structure of HIV-1 CA146 A92E real cell Descriptor: CHLORIDE ION, Gag-Pol polyprotein Authors: Kelly, B.N. Deposit date: 2007-05-11 Release date: 2007-09-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2P55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP Descriptor: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Ohren, J.F, Pavlovsky, A.G. Deposit date: 2007-03-14 Release date: 2007-10-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007
2OJJ	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, Mitogen-activated protein kinase 1, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJI	Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJG	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2M8P	The structure of the W184AM185A mutant of the HIV-1 capsid protein Descriptor: Capsid protein p24 Authors: Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. Deposit date: 2013-05-24 Release date: 2013-11-20 Last modified: 2023-06-14 Method: SOLUTION NMR, SOLUTION SCATTERING Cite: Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2M8N	HIV-1 capsid monomer structure Descriptor: Capsid protein p24 Authors: Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. Deposit date: 2013-05-24 Release date: 2013-11-20 Last modified: 2023-06-14 Method: SOLUTION NMR, SOLUTION SCATTERING Cite: Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2M8L	HIV capsid dimer structure Descriptor: Capsid protein p24 Authors: Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. Deposit date: 2013-05-23 Release date: 2013-11-20 Last modified: 2023-06-14 Method: SOLUTION NMR, SOLUTION SCATTERING Cite: Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2LF4	Structure of a monomeric mutant of the HIV-1 capsid protein Descriptor: Gag polyprotein Authors: Shin, R.S, Tzou, Y, Krishna, N. Deposit date: 2011-06-28 Release date: 2011-11-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure of a Monomeric Mutant of the HIV-1 Capsid Protein. Biochemistry, 50, 2011

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