3DY7

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

Summary for 3DY7

• Entry DOI: 10.2210/pdb3dy7/pdb
• Related: 1S9I 1S9J
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: dual specificity protein kinase, non-atp-competitive kinase inhibitor, inhibitor-bound protein kinase, atp-bound protein kinase, acetylation, atp-binding, disease mutation, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38914.26

Authors

Ohren, J.F.,Pavlovsky, A.,Zhang, E. (deposition date: 2008-07-25, release date: 2009-06-16, Last modification date: 2023-08-30)

• Primary citation: Tecle, H.,Shao, J.,Li, Y.,Kothe, M.,Kazmirski, S.,Penzotti, J.,Ding, Y.H.,Ohren, J.,Moshinsky, D.,Coli, R.,Jhawar, N.,Bora, E.,Jacques-O'Hagan, S.,Wu, J.; Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?; Bioorg.Med.Chem.Lett., 19:226-229, 2009; PubMed: 19019675; DOI: 10.1016/j.bmcl.2008.10.108

Experimental method

X-RAY DIFFRACTION (2.7 Å)