3DY7

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity mitogen-activated protein kinase kinase 1	polymer	341	37930.6	1	UniProt (Q02750) Pfam (PF00069) In PDB	Homo sapiens (Human)	MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1
2	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
4	A	(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide	non-polymer		452.2	1	Chemie (1CX)

Sequence modifications

A: 62 - 393 (UniProt: Q02750)

PDB	External Database	Details
Met 61	-	expression tag
Leu 394	-	expression tag
Glu 395	-	expression tag
His 396	-	expression tag
His 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
His 400	-	expression tag
His 401	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37930.6
Non-Polymers*	Number of molecules	3
	Total formula weight	983.7
All*	Total formula weight	38914.3

*Water molecules are not included.