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2OJJ

Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide

Summary for 2OJJ
Entry DOI10.2210/pdb2ojj/pdb
Related2OJG 2OJI 2OK1
DescriptorMitogen-activated protein kinase 1, SULFATE ION, (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordskinase inhibitor, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains1
Total formula weight44171.37
Authors
Xie, X.,Jacobs, M.D. (deposition date: 2007-01-12, release date: 2007-02-06, Last modification date: 2023-12-27)
Primary citationAronov, A.M.,Baker, C.,Bemis, G.W.,Cao, J.,Chen, G.,Ford, P.J.,Germann, U.A.,Green, J.,Hale, M.R.,Jacobs, M.,Janetka, J.W.,Maltais, F.,Martinez-Botella, G.,Namchuk, M.N.,Straub, J.,Tang, Q.,Xie, X.
Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors.
J.Med.Chem., 50:1280-1287, 2007
Cited by
PubMed: 17300186
DOI: 10.1021/jm061381f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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