2OJJ
Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 1 | polymer | 380 | 43616.0 | 1 | UniProt (P28482) Pfam (PF00069) In PDB | Homo sapiens (human) | Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1 |
2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
3 | A | (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE | non-polymer | 459.3 | 1 | Chemie (82A) | |||
4 | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A: 0 - 358 (UniProt: P28482)
PDB | External Database | Details |
---|---|---|
Met -21 | - | cloning artifact |
Gly -20 | - | cloning artifact |
Ser -19 | - | cloning artifact |
Ser -18 | - | cloning artifact |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
Ser -11 | - | cloning artifact |
Ser -10 | - | cloning artifact |
Gly -9 | - | cloning artifact |
Leu -8 | - | cloning artifact |
Val -7 | - | cloning artifact |
Pro -6 | - | cloning artifact |
Arg -5 | - | cloning artifact |
Gly -4 | - | cloning artifact |
Ser -3 | - | cloning artifact |
His -2 | - | cloning artifact |
Met -1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 43616.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 555.4 | |
All* | Total formula weight | 44171.4 |