2OJI
Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
Summary for 2OJI
Entry DOI | 10.2210/pdb2oji/pdb |
Related | 2OJG 2OJJ 2OK1 |
Descriptor | Mitogen-activated protein kinase 1, SULFATE ION, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 1 |
Total formula weight | 44088.91 |
Authors | Xie, X.,Jacobs, M.D. (deposition date: 2007-01-12, release date: 2007-02-06, Last modification date: 2023-12-27) |
Primary citation | Aronov, A.M.,Baker, C.,Bemis, G.W.,Cao, J.,Chen, G.,Ford, P.J.,Germann, U.A.,Green, J.,Hale, M.R.,Jacobs, M.,Janetka, J.W.,Maltais, F.,Martinez-Botella, G.,Namchuk, M.N.,Straub, J.,Tang, Q.,Xie, X. Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50:1280-1287, 2007 Cited by PubMed: 17300186DOI: 10.1021/jm061381f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report