2OJI

Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 1	polymer	380	43616.0	1	UniProt (P28482) Pfam (PF00069) In PDB	Homo sapiens (human)	Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE	non-polymer		376.8	1	Chemie (33A)
4		water	water		18.0	101	Chemie (HOH)

Sequence modifications

A: 0 - 358 (UniProt: P28482)

PDB	External Database	Details
Met -21	-	cloning artifact
Gly -20	-	cloning artifact
Ser -19	-	cloning artifact
Ser -18	-	cloning artifact
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	cloning artifact
Ser -10	-	cloning artifact
Gly -9	-	cloning artifact
Leu -8	-	cloning artifact
Val -7	-	cloning artifact
Pro -6	-	cloning artifact
Arg -5	-	cloning artifact
Gly -4	-	cloning artifact
Ser -3	-	cloning artifact
His -2	-	cloning artifact
Met -1	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43616.0
Non-Polymers*	Number of molecules	2
	Total formula weight	472.9
All*	Total formula weight	44088.9

*Water molecules are not included.