3DV3

MEK1 with PF-04622664 Bound

Summary for 3DV3

Entry DOI	10.2210/pdb3dv3/pdb
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	kinase, kinase inhibitors, mek, atp-binding, disease mutation, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
Total number of polymer chains	1
Total formula weight	36961.17
Authors	Kazmirski, S.L.,Kothe, M.,Ding, Y.-H. (deposition date: 2008-07-18, release date: 2009-07-21, Last modification date: 2024-02-21)
Primary citation	Tecle, H.,Shao, J.,Li, Y.,Kothe, M.,Kazmirski, S.,Penzotti, J.,Ding, Y.H.,Ohren, J.,Moshinsky, D.,Coli, R.,Jhawar, N.,Bora, E.,Jacques-O'Hagan, S.,Wu, J. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19:226-229, 2009 Cited by PubMed: 19019675 DOI: 10.1016/j.bmcl.2008.10.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation