3DV3
MEK1 with PF-04622664 Bound
Summary for 3DV3
| Entry DOI | 10.2210/pdb3dv3/pdb |
| Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total) |
| Functional Keywords | kinase, kinase inhibitors, mek, atp-binding, disease mutation, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750 |
| Total number of polymer chains | 1 |
| Total formula weight | 36961.17 |
| Authors | Kazmirski, S.L.,Kothe, M.,Ding, Y.-H. (deposition date: 2008-07-18, release date: 2009-07-21, Last modification date: 2024-02-21) |
| Primary citation | Tecle, H.,Shao, J.,Li, Y.,Kothe, M.,Kazmirski, S.,Penzotti, J.,Ding, Y.H.,Ohren, J.,Moshinsky, D.,Coli, R.,Jhawar, N.,Bora, E.,Jacques-O'Hagan, S.,Wu, J. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19:226-229, 2009 Cited by PubMed Abstract: An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK. PubMed: 19019675DOI: 10.1016/j.bmcl.2008.10.108 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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