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3EQD

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P

Summary for 3EQD
Entry DOI10.2210/pdb3eqd/pdb
Related3EQC 3EQF 3EQG 3EQH 3EQI
DescriptorDual specificity mitogen-activated protein kinase kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsmek1 kinase, atp-binding, disease mutation, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight40723.83
Authors
Fischmann, T.O. (deposition date: 2008-09-30, release date: 2009-02-24, Last modification date: 2024-02-21)
Primary citationFischmann, T.O.,Smith, C.K.,Mayhood, T.W.,Myers, J.E.,Reichert, P.,Mannarino, A.,Carr, D.,Zhu, H.,Wong, J.,Yang, R.S.,Le, H.V.,Madison, V.S.
Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
Biochemistry, 48:2661-2674, 2009
Cited by
PubMed: 19161339
DOI: 10.1021/bi801898e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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