3EQF
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P
Summary for 3EQF
Entry DOI | 10.2210/pdb3eqf/pdb |
Related | 3EQC 3EQD 3EQG 3EQH 3EQI |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, K-252A, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | mek1 kinase, atp-binding, disease mutation, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40668.06 |
Authors | Fischmann, T.O. (deposition date: 2008-09-30, release date: 2009-02-24, Last modification date: 2024-02-21) |
Primary citation | Fischmann, T.O.,Smith, C.K.,Mayhood, T.W.,Myers, J.E.,Reichert, P.,Mannarino, A.,Carr, D.,Zhu, H.,Wong, J.,Yang, R.S.,Le, H.V.,Madison, V.S. Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48:2661-2674, 2009 Cited by PubMed: 19161339DOI: 10.1021/bi801898e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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