3EQF
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 360 | 40113.2 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (Human) | MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1 |
| 2 | B (A) | K-252A | non-polymer | 467.5 | 1 | Chemie (KSA) PubChem (3813) PubChem (3035817) PubChem (490561) PubChem (6610352) PubChem (9890741) PubChem (9912410) PubChem (9912412) PubChem (9912413) PubChem (11612445) PubChem (24867866) PubChem (49868185) PubChem (127357) PubChem (162981511) PubChem (98053103) PubChem (98118654) PubChem (101713437) PubChem (102446520) PubChem (144411107) PubChem (162981512) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 5 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 6 | F (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 35 - 393 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 34 | - | expression tag |
| Asn 298 | Ser 298 | engineered mutation |
| Lys 299 | Ser 299 | engineered mutation |
| Phe 300 | Tyr 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40113.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 554.8 | |
| All* | Total formula weight | 40668.1 |
