3AVR
| Catalytic fragment of UTX/KDM6A bound with histone H3K27me3 peptide, N-oxyalylglycine, and Ni(II) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Histone H3, ... | 著者 | Sengoku, T, Yokoyama, S. | 登録日 | 2011-03-07 | 公開日 | 2011-10-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A Genes Dev., 25, 2011
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4EYU
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4ASK
| CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1 | 分子名称: | 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, COBALT (II) ION, LYSINE-SPECIFIC DEMETHYLASE 6B, ... | 著者 | Chung, C, Mosley, J, Liddle, J. | 登録日 | 2012-05-01 | 公開日 | 2012-07-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response Nature, 488, 2012
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4EZH
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4EZ4
| free KDM6B structure | 分子名称: | Lysine-specific demethylase 6B, N-OXALYLGLYCINE, NICKEL (II) ION, ... | 著者 | Cheng, Z.J, Patel, D.J. | 登録日 | 2012-05-02 | 公開日 | 2012-08-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature, 488, 2012
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4HCZ
| PHF1 Tudor in complex with H3K36me3 | 分子名称: | H3L-like histone, PHD finger protein 1 | 著者 | Musselman, C.A, Roy, S, Nunez, J, Kutateladze, T.G. | 登録日 | 2012-10-01 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat.Struct.Mol.Biol., 19, 2012
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4BD3
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2M0O
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4MI0
| Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) | 分子名称: | Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION | 著者 | Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2013-08-30 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
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4MN3
| Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7) | 分子名称: | 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Chromobox protein homolog 7, ... | 著者 | Chakravarthi, S, Daze, K, Douglas, S, Quon, T, Dev, A, Peng, F, Heller, M, Boulanger, M.J, Wulff, J, Hof, F. | 登録日 | 2013-09-09 | 公開日 | 2014-04-02 | 最終更新日 | 2014-10-08 | 実験手法 | X-RAY DIFFRACTION (1.542 Å) | 主引用文献 | Chromodomain Antagonists That Target the Polycomb-Group Methyllysine Reader Protein Chromobox Homolog 7 (CBX7). J.Med.Chem., 57, 2014
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2MJ8
| Solution structure of CDYL2 chromodomain | 分子名称: | Chromodomain Y-like protein 2 | 著者 | Qin, S, Houliston, S, Arrowsmith, C.H, Edwards, A.M, Wu, H, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2013-12-28 | 公開日 | 2014-04-23 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol, 27, 2020
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4RGW
| Crystal Structure of a TAF1-TAF7 Complex in Human Transcription Factor IID | 分子名称: | GLYCEROL, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 7 | 著者 | Wang, H, Curran, E.C, Hinds, T.R, Wang, E.H, Zheng, N. | 登録日 | 2014-09-30 | 公開日 | 2014-12-03 | 最終更新日 | 2014-12-17 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Cell Res., 24, 2014
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4V2V
| JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA | 分子名称: | CHLORIDE ION, HISTONE H3.1T, LYSINE-SPECIFIC DEMETHYLASE 4A, ... | 著者 | Chowdhury, R, Madden, S.K, Schofield, C.J. | 登録日 | 2014-10-15 | 公開日 | 2014-11-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates. Epigenetics, 9, 2014
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4V2W
| JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (16-35) | 分子名称: | CHLORIDE ION, GLYCEROL, HISTONE H3.1T, ... | 著者 | Chowdhury, R, Zafred, D, Schofield, C.J. | 登録日 | 2014-10-15 | 公開日 | 2014-11-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates. Epigenetics, 9, 2014
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4X3E
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4X3K
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4X3U
| Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin | 分子名称: | 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Chromobox protein homolog 7 | 著者 | Ren, C, Zhou, M.M. | 登録日 | 2014-12-01 | 公開日 | 2015-03-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
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4X3S
| Crystal structure of chromobox homology 7 (CBX7) with SETDB1-1170me3 Peptide | 分子名称: | CITRIC ACID, Chromobox protein homolog 7, FE (III) ION, ... | 著者 | Ren, C, Plotnikov, A.N, Zhou, M.M. | 登録日 | 2014-12-01 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
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4X3T
| Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS37452 | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone, Chromobox protein homolog 7, ... | 著者 | Ren, C, Jakoncic, J, Zhou, M.M. | 登録日 | 2014-12-01 | 公開日 | 2015-03-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
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2N4Q
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5EJW
| Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351 | 分子名称: | (1~{R})-2-[2-azanylidene-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]-1-(3,4-dichlorophenyl)ethanol, Chromobox protein homolog 7 | 著者 | Ren, C, Zhou, M.M. | 登録日 | 2015-11-02 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7. Acs Med.Chem.Lett., 7, 2016
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5EPK
| Crystal Structure of chromodomain of CBX2 in complex with inhibitor UNC3866 | 分子名称: | Chromobox protein homolog 2, UNKNOWN ATOM OR ION, unc3866 | 著者 | Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-11-11 | 公開日 | 2015-12-23 | 最終更新日 | 2019-11-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol., 12, 2016
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5EPL
| Crystal Structure of chromodomain of CBX4 in complex with inhibitor UNC3866 | 分子名称: | E3 SUMO-protein ligase CBX4, UNKNOWN ATOM OR ION, unc3866 | 著者 | Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-11-11 | 公開日 | 2015-12-23 | 最終更新日 | 2019-11-27 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol., 12, 2016
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5EQ0
| Crystal Structure of chromodomain of CBX8 in complex with inhibitor UNC3866 | 分子名称: | Chromobox protein homolog 8, UNKNOWN ATOM OR ION, unc3866 | 著者 | Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-11-12 | 公開日 | 2015-12-23 | 最終更新日 | 2019-11-27 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol., 12, 2016
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5FUR
| Structure of human TFIID-IIA bound to core promoter DNA | 分子名称: | SUPER CORE PROMOTER, TATA-BOX-BINDING PROTEIN, TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1, ... | 著者 | Louder, R.K, He, Y, Lopez-Blanco, J.R, Fang, J, Chacon, P, Nogales, E. | 登録日 | 2016-01-29 | 公開日 | 2016-04-06 | 最終更新日 | 2017-08-02 | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | 主引用文献 | Structure of Promoter-Bound TFIID and Model of Human Pre-Initiation Complex Assembly. Nature, 531, 2016
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