5EJW
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351
Summary for 5EJW
| Entry DOI | 10.2210/pdb5ejw/pdb |
| Descriptor | Chromobox protein homolog 7, (1~{R})-2-[2-azanylidene-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]-1-(3,4-dichlorophenyl)ethanol (3 entities in total) |
| Functional Keywords | transcription, inhibitor, transcription-inhibitor complex, transcription/inhibitor |
| Biological source | Mus musculus (Mouse) |
| Cellular location | Nucleus : Q8VDS3 |
| Total number of polymer chains | 1 |
| Total formula weight | 11153.57 |
| Authors | Ren, C.,Zhou, M.M. (deposition date: 2015-11-02, release date: 2016-03-09, Last modification date: 2023-09-27) |
| Primary citation | Ren, C.,Smith, S.G.,Yap, K.,Li, S.,Li, J.,Mezei, M.,Rodriguez, Y.,Vincek, A.,Aguilo, F.,Walsh, M.J.,Zhou, M.M. Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7. Acs Med.Chem.Lett., 7:601-605, 2016 Cited by PubMed: 27326334DOI: 10.1021/acsmedchemlett.6b00042 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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