4X3E

Crystal structure of EED in complex with a trimethylated Jarid2 peptide

Summary for 4X3E

• Entry DOI: 10.2210/pdb4x3e/pdb
• Descriptor: Polycomb protein EED, ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER (3 entities in total)
• Functional Keywords: gene regulation, histone binding, wd40, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: O75530
• Total number of polymer chains: 2
• Total formula weight: 43983.06

Authors

Justin, N.,Gamblin, S.J.,Margueron, R. (deposition date: 2014-11-28, release date: 2015-01-21, Last modification date: 2024-01-10)

• Primary citation: Sanulli, S.,Justin, N.,Teissandier, A.,Ancelin, K.,Portoso, M.,Caron, M.,Michaud, A.,Lombard, B.,da Rocha, S.T.,Offer, J.,Loew, D.,Servant, N.,Wassef, M.,Burlina, F.,Gamblin, S.J.,Heard, E.,Margueron, R.; Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.; Mol.Cell, 57:769-783, 2015; PubMed: 25620564; DOI: 10.1016/j.molcel.2014.12.020

Experimental method

X-RAY DIFFRACTION (2.3 Å)