4EZH

the crystal structure of KDM6B bound with H3K27me3 peptide

Summary for 4EZH

Entry DOI	10.2210/pdb4ezh/pdb
Related	4ASK 4EYU 4EZ4
Descriptor	Lysine-specific demethylase 6B, SYNTHESIZED methylation peptide, NICKEL (II) ION, ... (6 entities in total)
Functional Keywords	jmjc, histone demethylase, histone k27me3/me2 'eraser', oxidoreductase
Biological source	Mus musculus (mouse) More
Cellular location	Nucleus : Q5NCY0
Total number of polymer chains	4
Total formula weight	112374.67
Authors	Cheng, Z.J.,Patel, D.J. (deposition date: 2012-05-02, release date: 2012-08-08, Last modification date: 2017-08-09)
Primary citation	Kruidenier, L.,Chung, C.W.,Cheng, Z.,Liddle, J.,Che, K.,Joberty, G.,Bantscheff, M.,Bountra, C.,Bridges, A.,Diallo, H.,Eberhard, D.,Hutchinson, S.,Jones, E.,Katso, R.,Leveridge, M.,Mander, P.K.,Mosley, J.,Ramirez-Molina, C.,Rowland, P.,Schofield, C.J.,Sheppard, R.J.,Smith, J.E.,Swales, C.,Tanner, R.,Thomas, P.,Tumber, A.,Drewes, G.,Oppermann, U.,Patel, D.J.,Lee, K.,Wilson, D.M. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature, 488:404-408, 2012 Cited by PubMed: 22842901 DOI: 10.1038/nature11262 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.52 Å)

Structure validation