4EZH
the crystal structure of KDM6B bound with H3K27me3 peptide
Summary for 4EZH
Entry DOI | 10.2210/pdb4ezh/pdb |
Related | 4ASK 4EYU 4EZ4 |
Descriptor | Lysine-specific demethylase 6B, SYNTHESIZED methylation peptide, NICKEL (II) ION, ... (6 entities in total) |
Functional Keywords | jmjc, histone demethylase, histone k27me3/me2 'eraser', oxidoreductase |
Biological source | Mus musculus (mouse) More |
Cellular location | Nucleus : Q5NCY0 |
Total number of polymer chains | 4 |
Total formula weight | 112374.67 |
Authors | Cheng, Z.J.,Patel, D.J. (deposition date: 2012-05-02, release date: 2012-08-08, Last modification date: 2017-08-09) |
Primary citation | Kruidenier, L.,Chung, C.W.,Cheng, Z.,Liddle, J.,Che, K.,Joberty, G.,Bantscheff, M.,Bountra, C.,Bridges, A.,Diallo, H.,Eberhard, D.,Hutchinson, S.,Jones, E.,Katso, R.,Leveridge, M.,Mander, P.K.,Mosley, J.,Ramirez-Molina, C.,Rowland, P.,Schofield, C.J.,Sheppard, R.J.,Smith, J.E.,Swales, C.,Tanner, R.,Thomas, P.,Tumber, A.,Drewes, G.,Oppermann, U.,Patel, D.J.,Lee, K.,Wilson, D.M. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature, 488:404-408, 2012 Cited by PubMed: 22842901DOI: 10.1038/nature11262 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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