4EZH

the crystal structure of KDM6B bound with H3K27me3 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Lysine-specific demethylase 6B	polymer	486	54886.0	2	UniProt (Q5NCY0) Pfam (PF02373) Pfam (PF21322) Pfam (PF21326)	Mus musculus (mouse)	JmjC domain-containing protein 3, Jumonji domain-containing protein 3
2	C, D (C, D)	SYNTHESIZED methylation peptide	polymer	11	1030.2	2	UniProt (by SIFTS) (P68431)	synthetic construct
3	E, H (A, B)	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)
4	F, I (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	G, J (A, B)	N-OXALYLGLYCINE	non-polymer		147.1	2	Chemie (OGA)
6	K, L (A, B)	water	water		18.0	82	Chemie (HOH)

Sequence modifications

A, B: 1157 - 1295 (UniProt: Q5NCY0)
A, B: 1323 - 1643 (UniProt: Q5NCY0)

PDB	External Database	Details
Leu 1296	-	SEE REMARK 999
Glu 1297	-	SEE REMARK 999
Val 1298	-	SEE REMARK 999
Leu 1299	-	SEE REMARK 999
Phe 1300	-	SEE REMARK 999
Gln 1301	-	SEE REMARK 999
Gly 1303	-	SEE REMARK 999
Pro 1304	-	SEE REMARK 999
Thr 1305	-	SEE REMARK 999
Lys 1306	-	SEE REMARK 999
Ala 1307	-	SEE REMARK 999
Ala 1308	-	SEE REMARK 999
Arg 1309	-	SEE REMARK 999
Lys 1310	-	SEE REMARK 999
Ser 1311	-	SEE REMARK 999
Ala 1312	-	SEE REMARK 999
Pro 1313	-	SEE REMARK 999
Ala 1314	-	SEE REMARK 999
Thr 1315	-	SEE REMARK 999
Gly 1316	-	SEE REMARK 999
Gly 1317	-	SEE REMARK 999
Gly 1318	-	SEE REMARK 999
Ser 1319	-	SEE REMARK 999
Ser 1320	-	SEE REMARK 999
Gly 1321	-	SEE REMARK 999
Ser 1322	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	111832.3
Non-Polymers*	Number of molecules	6
	Total formula weight	542.4
All*	Total formula weight	112374.7

*Water molecules are not included.