PDB: 62 件ウェブページステータス検索Chemie searchBIRD

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7DMY	The crystal structure of Cpd7 in complex with BPTF bromodomain 分子名称: Nucleosome-remodeling factor subunit BPTF, tert-butyl 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-4-oxidanylidene-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate 著者 Xiong, L, Guo, Y, Yang, S. 登録日 2020-12-08 公開日 2021-10-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization. Biochem.Biophys.Res.Commun., 545, 2021
7DN4	The crystal structure of Cpd8 in complex with BPTF bromodomain 分子名称: 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-one, Nucleosome-remodeling factor subunit BPTF 著者 Xiong, L, Guo, Y, Yang, S. 登録日 2020-12-08 公開日 2021-10-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.841 Å) 主引用文献 Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization. Biochem.Biophys.Res.Commun., 545, 2021
8AG2	Crystal structure of the BPTF bromodomain in complex with BI-7190 分子名称: 5-[3-methoxy-4-[1-(4-methylpiperazin-1-yl)cyclopropyl]phenyl]-1,3,4-trimethyl-pyridin-2-one, Nucleosome-remodeling factor subunit BPTF 著者 Bader, G, Boettcher, J, Wolkerstorfer, B. 登録日 2022-07-19 公開日 2022-08-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.025 Å) 主引用文献 Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. Chemmedchem, 18, 2023
3QZV	Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF, ZINC ION 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
3QZT	Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II 分子名称: GLYCEROL, Histone H4, Nucleosome-remodeling factor subunit BPTF 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
3QZS	Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
7LRO	Crystal structure of BPTF bromodomain in complex with inhibitor HZ-01-105 分子名称: 1,2-ETHANEDIOL, 5-(azetidin-3-ylamino)-4-chloranyl-2-methyl-pyridazin-3-one, DIMETHYL SULFOXIDE, ... 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-17 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7LP0	Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-077 分子名称: 1,2-ETHANEDIOL, 4-chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one, DIMETHYL SULFOXIDE, ... 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-11 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7LRK	Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-093 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-2-methyl-5-[[(3~{S})-pyrrolidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-16 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7RWP	Crystal Structure of BPTF bromodomain in complex with 5-[4-(aminomethyl)anilino]-4-chloro-2-methylpyridazin-3(2H)-one 分子名称: 5-[4-(aminomethyl)anilino]-4-chloro-2-methylpyridazin-3(2H)-one, CALCIUM ION, Nucleosome-remodeling factor subunit BPTF 著者 Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. 登録日 2021-08-20 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7RWN	Crystal Structure of BPTF bromodomain in complex with 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one 分子名称: 1,2-ETHANEDIOL, 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF 著者 Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. 登録日 2021-08-20 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7RWQ	Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one 分子名称: 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one, CALCIUM ION, Nucleosome-remodeling factor subunit BPTF 著者 Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. 登録日 2021-08-20 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7RWO	Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyridazin-3(2H)-one 分子名称: 1,2-ETHANEDIOL, 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF 著者 Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. 登録日 2021-08-20 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7LPK	Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-2-methyl-5-[[(3~{R})-pyrrolidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-12 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7K6R	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to GSK4027 分子名称: 1,2-ETHANEDIOL, 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2020-09-21 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18, 2020
7K6S	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 4 (SKT1174) 分子名称: (7-amino-3,4-dihydroquinolin-1(2H)-yl)(cyclopropyl)methanone, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Chan, A, Schonbrunn, E. 登録日 2020-09-21 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18, 2020
7KDW	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 6 (HZ01052) 分子名称: 1,2-ETHANEDIOL, Nucleosome-remodeling factor subunit BPTF, cyclopropyl[7-({2-[(prop-2-yn-1-yl)amino]pyrimidin-4-yl}amino)-3,4-dihydroquinolin-1(2H)-yl]methanone 著者 Chan, A, Schonbrunn, E. 登録日 2020-10-09 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development Organic and Biomolecular Chemistry, 18(27), 2020
7KDZ	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to TP-238 分子名称: 1,2-ETHANEDIOL, 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2020-10-09 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development Organic & Biomolecular Chemistry, 18(27), 2020
7JT4	Crystal Structure of BPTF bromodomain labelled with 5-fluoro-tryptophan 分子名称: Nucleosome-remodeling factor subunit BPTF 著者 Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. 登録日 2020-08-17 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor Org.Biomol.Chem., 17, 2019
5H6Y	The BPTF Bromodomain Recognising H4K12Cr peptide 分子名称: GLY-KCR-GLY, Nucleosome-remodeling factor subunit BPTF 著者 Wang, Y, Hao, Q. 登録日 2016-11-15 公開日 2017-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The BPTF Bromodomain Recognising H4K12Cr peptide To Be Published
7M2E	Crystal structure of BPTF bromodomain in complex with CB02-092 分子名称: 4-chloro-5-{4-[2-(dimethylamino)ethyl]anilino}-2-methylpyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF 著者 Nithianantham, S, Fischer, M. 登録日 2021-03-16 公開日 2022-02-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition J.Med.Chem., 64, 2021
2RI7	Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Nucleosome-remodeling factor subunit BPTF, ... 著者 Li, H, Patel, D.J. 登録日 2007-10-10 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
6LU5	Crystal structure of BPTF-BRD with ligand DCBPin5 bound 分子名称: 6-(1H-indol-5-yl)-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF 著者 Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. 登録日 2020-01-25 公開日 2021-04-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.86527729 Å) 主引用文献 Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins To Be Published
6LU6	Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound 分子名称: 6-[1-[3-(dimethylamino)propyl]indol-5-yl]-2-methylsulfonyl-N-propyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF 著者 Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. 登録日 2020-01-26 公開日 2021-04-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.970063 Å) 主引用文献 Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins To Be Published
2FUU	NMR solution structure of the PHD domain from the human BPTF in complex with H3(1-15)K4me3 peptide 分子名称: Histone H3, ZINC ION, bromodomain PHD finger transcription factor 著者 Ilin, S, Patel, D.J. 登録日 2006-01-27 公開日 2006-07-11 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006

 

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