7DN4

The crystal structure of Cpd8 in complex with BPTF bromodomain

Summary for 7DN4

• Entry DOI: 10.2210/pdb7dn4/pdb
• Descriptor: Nucleosome-remodeling factor subunit BPTF, 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-one (2 entities in total)
• Functional Keywords: inhibitor, bptf, bromodomain, reader, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 88763.17

Authors

Xiong, L.,Guo, Y.,Yang, S. (deposition date: 2020-12-08, release date: 2021-10-20, Last modification date: 2023-11-29)

• Primary citation: Xiong, L.,Mao, X.,Guo, Y.,Zhou, Y.,Chen, M.,Chen, P.,Yang, S.,Li, L.; Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization.; Biochem.Biophys.Res.Commun., 545:125-131, 2021; PubMed: 33548625; DOI: 10.1016/j.bbrc.2021.01.067

Experimental method

X-RAY DIFFRACTION (2.841 Å)