7K6S
Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 4 (SKT1174)
Summary for 7K6S
| Entry DOI | 10.2210/pdb7k6s/pdb |
| Descriptor | Nucleosome-remodeling factor subunit BPTF, (7-amino-3,4-dihydroquinolin-1(2H)-yl)(cyclopropyl)methanone, 1,2-ETHANEDIOL, ... (6 entities in total) |
| Functional Keywords | brd, phd, gene regulation, fac1, falz, nucleosome-remodeling factor subunit |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 14861.31 |
| Authors | Chan, A.,Schonbrunn, E. (deposition date: 2020-09-21, release date: 2020-12-09, Last modification date: 2023-10-18) |
| Primary citation | Ycas, P.D.,Zahid, H.,Chan, A.,Olson, N.M.,Johnson, J.A.,Talluri, S.K.,Schonbrunn, E.,Pomerantz, W.C.K. New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18:5174-5182, 2020 Cited by PubMed: 32588860DOI: 10.1039/d0ob00506a PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.23 Å) |
Structure validation
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