8AG2

Crystal structure of the BPTF bromodomain in complex with BI-7190

Summary for 8AG2

Entry DOI	10.2210/pdb8ag2/pdb
Descriptor	Nucleosome-remodeling factor subunit BPTF, 5-[3-methoxy-4-[1-(4-methylpiperazin-1-yl)cyclopropyl]phenyl]-1,3,4-trimethyl-pyridin-2-one (3 entities in total)
Functional Keywords	bromodomain, inhibitor, complex, protein binding
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	14618.65
Authors	Bader, G.,Boettcher, J.,Wolkerstorfer, B. (deposition date: 2022-07-19, release date: 2022-08-31, Last modification date: 2024-02-07)
Primary citation	Martinelli, P.,Schaaf, O.,Mantoulidis, A.,Martin, L.J.,Fuchs, J.E.,Bader, G.,Gollner, A.,Wolkerstorfer, B.,Rogers, C.,Balikci, E.,Lipp, J.J.,Mischerikow, N.,Doebel, S.,Gerstberger, T.,Sommergruber, W.,Huber, K.V.M.,Bottcher, J. Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. Chemmedchem, 18:e202200686-e202200686, 2023 Cited by PubMed: 36649575 DOI: 10.1002/cmdc.202200686 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.025 Å)

Structure validation