7M2E

Crystal structure of BPTF bromodomain in complex with CB02-092

Summary for 7M2E

Entry DOI	10.2210/pdb7m2e/pdb
Descriptor	Nucleosome-remodeling factor subunit BPTF, 4-chloro-5-{4-[2-(dimethylamino)ethyl]anilino}-2-methylpyridazin-3(2H)-one (3 entities in total)
Functional Keywords	bptf, bromodomain, bromodomain inhibitor, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14762.21
Authors	Nithianantham, S.,Fischer, M. (deposition date: 2021-03-16, release date: 2022-02-16, Last modification date: 2023-10-18)
Primary citation	Zahid, H.,Buchholz, C.R.,Singh, M.,Ciccone, M.F.,Chan, A.,Nithianantham, S.,Shi, K.,Aihara, H.,Fischer, M.,Schonbrunn, E.,dos Santos, C.O.,Landry, J.W.,Pomerantz, W.C.K. New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition J.Med.Chem., 64:13902-13917, 2021 Cited by DOI: 10.1021/acs.jmedchem.1c01294 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation