7DMY
The crystal structure of Cpd7 in complex with BPTF bromodomain
Summary for 7DMY
Entry DOI | 10.2210/pdb7dmy/pdb |
Descriptor | Nucleosome-remodeling factor subunit BPTF, tert-butyl 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-4-oxidanylidene-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate (3 entities in total) |
Functional Keywords | inhibitor;bptf;bromodomain, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17366.64 |
Authors | |
Primary citation | Xiong, L.,Mao, X.,Guo, Y.,Zhou, Y.,Chen, M.,Chen, P.,Yang, S.,Li, L. Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization. Biochem.Biophys.Res.Commun., 545:125-131, 2021 Cited by PubMed: 33548625DOI: 10.1016/j.bbrc.2021.01.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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