7DMY

The crystal structure of Cpd7 in complex with BPTF bromodomain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nucleosome-remodeling factor subunit BPTF	polymer	144	16927.1	1	UniProt (Q12830) Pfam (PF00439)	Homo sapiens (Human)	Bromodomain and PHD finger-containing transcription factor,Fetal Alz-50 clone 1 protein,Fetal Alzheimer antigen
2	B (A)	tert-butyl 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-4-oxidanylidene-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate	non-polymer		439.6	1	Chemie (HAF)
3	C (A)	water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 2791 - 2911 (UniProt: Q12830)

PDB	External Database	Details
Met 2768	-	initiating methionine
His 2769	-	expression tag
His 2770	-	expression tag
His 2771	-	expression tag
His 2772	-	expression tag
His 2773	-	expression tag
His 2774	-	expression tag
Ser 2775	-	expression tag
Ser 2776	-	expression tag
Gly 2777	-	expression tag
Val 2778	-	expression tag
Asp 2779	-	expression tag
Leu 2780	-	expression tag
Gly 2781	-	expression tag
Thr 2782	-	expression tag
Glu 2783	-	expression tag
Asn 2784	-	expression tag
Leu 2785	-	expression tag
Tyr 2786	-	expression tag
Phe 2787	-	expression tag
Gln 2788	-	expression tag
Ser 2789	-	expression tag
Met 2790	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16927.1
Non-Polymers*	Number of molecules	1
	Total formula weight	439.6
All*	Total formula weight	17366.6

*Water molecules are not included.