2RI7

Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state

Summary for 2RI7

Entry DOI	10.2210/pdb2ri7/pdb
Related	2F6J 2F6N 2FSA
Descriptor	Nucleosome-remodeling factor subunit BPTF, histone H3.1, ZINC ION, ... (6 entities in total)
Functional Keywords	zinc finger, alpha-helical bundle, dimethyl-lysine, bromodomain, chromatin regulator, metal-binding, nucleus, phosphorylation, transcription, transcription regulation, zinc-finger, transcription-nuclear protein complex, transcription/nuclear protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q12830 Nucleus: P68431
Total number of polymer chains	2
Total formula weight	21636.30
Authors	Li, H.,Patel, D.J. (deposition date: 2007-10-10, release date: 2007-12-11, Last modification date: 2023-08-30)
Primary citation	Li, H.,Fischle, W.,Wang, W.,Duncan, E.M.,Liang, L.,Murakami-Ishibe, S.,Allis, C.D.,Patel, D.J. Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28:677-691, 2007 Cited by PubMed: 18042461 DOI: 10.1016/j.molcel.2007.10.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation