2RI7

Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016589	cellular_component	NURF complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS11
A	CYS13
A	HIS34
A	CYS37

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS26
A	CYS29
A	CYS53
A	CYS56

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 503

Chain	Residue
A	GLN55
A	CYS56
A	VAL160
A	HOH789
A	CYS29

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IPA A 504

Chain	Residue
A	PRO92
A	CYS144
A	ASN148
A	HOH812

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. AwpFlepvDpndap..DYYgvIkepMdlatMeervqrry..Yekltefvadmtk.IfdNCryY

Chain	Residue	Details
A	ALA90-TYR147

---

site_id	PS01359
Number of Residues	46
Details	ZF_PHD_1 Zinc finger PHD-type signature. Ci.Cktpedeskfy...................................IgCdr..Cqnw.YHgrCvgilqseaelide................................YvCpqC

Chain	Residue	Details
A	CYS11-CYS56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	51
Details	Zinc finger: {"description":"PHD-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Histone H3K4me3 binding"}

Chain

Residue

Details

---