2RI7
Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Nucleosome-remodeling factor subunit BPTF | polymer | 174 | 20263.0 | 1 | UniProt (Q12830) Pfam (PF00628) Pfam (PF00439) In PDB | Homo sapiens (human) | Bromodomain and PHD finger- containing transcription factor, Fetal Alzheimer antigen, Fetal Alz- 50 clone 1 protein |
| 2 | P | histone H3.1 | polymer | 9 | 1090.3 | 1 | UniProt (P68431) In PDB | ||
| 3 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | A | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 6 | water | water | 18.0 | 337 | Chemie (HOH) |
Sequence modifications
A: 6 - 174 (UniProt: Q12830)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Pro 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Gly 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Glu 17 | Tyr 2737 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21353.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 283.0 | |
| All* | Total formula weight | 21636.3 |
