7KDZ

Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to TP-238

Summary for 7KDZ

Entry DOI	10.2210/pdb7kdz/pdb
Descriptor	Nucleosome-remodeling factor subunit BPTF, 1,2-ETHANEDIOL, 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine, ... (4 entities in total)
Functional Keywords	brd, phd, gene regulation, fac1, falz
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14976.06
Authors	Chan, A.,Schonbrunn, E. (deposition date: 2020-10-09, release date: 2020-12-09, Last modification date: 2023-10-18)
Primary citation	Ycas, P.D.,Zahid, H.,Chan, A.,Olson, N.M.,Johnson, J.A.,Talluri, S.K.,Schonbrunn, E.,Pomerantz, W.C.K. New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development Organic & Biomolecular Chemistry, 18(27):5174-5182, 2020 Cited by PubMed: 32588860 DOI: 10.1039/d0ob00506a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation