7KDZ
Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to TP-238
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Nucleosome-remodeling factor subunit BPTF | polymer | 123 | 14455.4 | 1 | UniProt (Q12830) Pfam (PF00439) In PDB | Homo sapiens (Human) | Bromodomain and PHD finger-containing transcription factor,Fetal Alz-50 clone 1 protein,Fetal Alzheimer antigen |
| 2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | A | 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine | non-polymer | 458.6 | 1 | Chemie (WCS) | |||
| 4 | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 2917 - 3037 (UniProt: Q12830)
| PDB | External Database | Details |
|---|---|---|
| Ser 2915 | - | expression tag |
| Met 2916 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14455.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 520.6 | |
| All* | Total formula weight | 14976.1 |
