7KDW

Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 6 (HZ01052)

Summary for 7KDW

Entry DOI	10.2210/pdb7kdw/pdb
Descriptor	Nucleosome-remodeling factor subunit BPTF, cyclopropyl[7-({2-[(prop-2-yn-1-yl)amino]pyrimidin-4-yl}amino)-3,4-dihydroquinolin-1(2H)-yl]methanone, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	brd, phd, gene regulation, fac1, falz, nucleosome-remodeling factor subunit
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29667.73
Authors	Chan, A.,Schonbrunn, E. (deposition date: 2020-10-09, release date: 2020-12-09, Last modification date: 2023-10-18)
Primary citation	Ycas, P.D.,Zahid, H.,Chan, A.,Olson, N.M.,Johnson, J.A.,Talluri, S.K.,Schonbrunn, E.,Pomerantz, W.C.K. New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development Organic and Biomolecular Chemistry, 18(27):5174-5182, 2020 Cited by PubMed: 32588860 DOI: 10.1039/d0ob00506a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation