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5VMN
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Crystal structure of grouper iridovirus GIV66
Descriptor: 1,2-ETHANEDIOL, Bak protein, NITRATE ION
Authors:Banjara, S, Kvansakul, M.
Deposit date:2017-04-27
Release date:2018-03-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.
J. Biol. Chem., 293, 2018
5W62
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Crystal structure of mouse BAX monomer
Descriptor: Apoptosis regulator BAX, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W5X
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BU of 5w5x by Molmil
Crystal structure of BAXP168G in complex with an activating antibody
Descriptor: 1,2-ETHANEDIOL, 3C10 Fab' heavy chain, 3C10 Fab' light chain, ...
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W5Z
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BU of 5w5z by Molmil
Crystal structure of BAXP168G in complex with an activating antibody at high resolution
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C10 Fab heavy chain, ...
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W60
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BU of 5w60 by Molmil
Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol
Descriptor: Apoptosis regulator BAX, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W61
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Crystal structure of BAXP168G monomer co-crystallized with glycerol
Descriptor: Apoptosis regulator BAX
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W63
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Crystal structure of channel catfish BAX
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator bax, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.436 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W89
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BU of 5w89 by Molmil
Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18
Authors:Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E.
Deposit date:2017-06-21
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5W8F
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BU of 5w8f by Molmil
Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-14
Authors:Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E.
Deposit date:2017-06-21
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5WHH
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BU of 5whh by Molmil
Crystal Structure of Bcl-2-related protein A1 in complex with stapled peptide (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2)
Descriptor: (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2), Bcl-2-related protein A1, CHLORIDE ION
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2017-07-17
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Structure, 26, 2018
1AF3
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BU of 1af3 by Molmil
RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN
Descriptor: APOPTOSIS REGULATOR BCL-X
Authors:Aritomi, M, Kunishima, N, Inohara, N, Ishibashi, Y, Ohta, S, Morikawa, K.
Deposit date:1997-03-21
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family.
J.Biol.Chem., 272, 1997
1BXL
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BU of 1bxl by Molmil
STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: BAK PEPTIDE, BCL-XL
Authors:Sattler, M, Liang, H, Nettesheim, D, Meadows, R.P, Harlan, J.E, Eberstadt, M, Yoon, H, Shuker, S.B, Chang, B.S, Minn, A.J, Thompson, C.B, Fesik, S.W.
Deposit date:1996-10-16
Release date:1997-10-29
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science, 275, 1997
6YLI
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BU of 6yli by Molmil
Crystal structure of human bcl-xL bound to trichoplax adhaerens trBak BH3
Descriptor: Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1, SULFATE ION
Authors:D Sa, J, Banjara, S, Kvansakul, M.
Deposit date:2020-04-07
Release date:2021-03-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis.
Sci Adv, 6, 2020
8U27
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BU of 8u27 by Molmil
Bcl-2-xL complexed with compound 35
Descriptor: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate
Authors:Rizo, J, Pan, Y.-Z.
Deposit date:2023-09-05
Release date:2023-09-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural insights for selective disruption of Beclin 1 binding to Bcl-2.
Commun Biol, 6, 2023
7CA4
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BU of 7ca4 by Molmil
The Crystal Structure of human Bcl-2-like protein 1 from Biortus
Descriptor: Bcl-2-like protein 1, SULFATE ION
Authors:Wang, F, Lv, Z, Lin, D, Huang, Y.
Deposit date:2020-06-08
Release date:2020-07-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Crystal Structure of human Bcl-2-like protein 1 from Biortus.
To Be Published
8XP5
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BU of 8xp5 by Molmil
The Crystal Structure of p53/BCL-xL fusion complex from Biortus.
Descriptor: Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION
Authors:Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C.
Deposit date:2024-01-03
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Crystal Structure of p53/BCL-xL fusion complex from Biortus.
To Be Published
8WLS
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BU of 8wls by Molmil
Bcl-xL in complex with HBx BH3 delta C peptide
Descriptor: Bcl-2-like protein 1, Protein X
Authors:Kobayashi, N, Nagata, T, Kusunoki, H.
Deposit date:2023-10-01
Release date:2024-03-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Insights into the Interaction between the C-Terminal-Deleted BH3-like Motif Peptide of Hepatitis B Virus X Protein and Bcl-x L.
Biochemistry, 63, 2024
7WJH
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BU of 7wjh by Molmil
Crystal structure of Bcl-xL bound to the BH3 domain of human Pxt1
Descriptor: Bcl-2-like protein 1, MAGNESIUM ION, Peroxisomal testis-specific protein 1, ...
Authors:Lim, D, Ku, B.
Deposit date:2022-01-06
Release date:2022-09-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1.
Biochem.Biophys.Res.Commun., 625, 2022
7XGF
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BU of 7xgf by Molmil
Crystal structure of BCL-xL in complex with computationally designed inhibitor protein
Descriptor: BCL-xL, BCL-xL and MCL-1 dual inhibitor 2
Authors:Oh, B.-H, Kim, S.
Deposit date:2022-04-04
Release date:2022-07-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently.
Comput Struct Biotechnol J, 20, 2022
7XGG
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BU of 7xgg by Molmil
Crystal structure of BCL-xL in complex with computationally designed inhibitor protein
Descriptor: BCL-xL and MCL-1 dual inhibitor, Bcl-2-like protein 1
Authors:Oh, B.-H, Kim, S.
Deposit date:2022-04-04
Release date:2022-07-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently.
Comput Struct Biotechnol J, 20, 2022
7JGV
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BU of 7jgv by Molmil
CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 1620116, CRYSTAL FORM 2
Descriptor: 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1
Authors:Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F.
Deposit date:2020-07-19
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Acs Infect Dis., 7, 2021
7JGW
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BU of 7jgw by Molmil
Crystal structure of BCL-XL in complex with COMPOUND 1620116, CRYSTAL FORM 1
Descriptor: 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1
Authors:Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F.
Deposit date:2020-07-19
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Acs Infect Dis., 7, 2021
1GJH
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BU of 1gjh by Molmil
HUMAN BCL-2, ISOFORM 2
Descriptor: PROTEIN (APOPTOSIS REGULATOR BCL-2 WITH PUTATIVE FLEXIBLE LOOP REPLACED WITH A PORTION OF APOPTOSIS REGULATOR BCL-X PROTEIN)
Authors:Petros, A.M, Medek, A, Nettesheim, D.G, Kim, D.H, Yoon, H.S, Swift, K, Matayoshi, E.D, Oltersdorf, T, Fesik, S.W.
Deposit date:2001-05-31
Release date:2001-06-13
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the antiapoptotic protein bcl-2.
Proc.Natl.Acad.Sci.USA, 98, 2001
1G5J
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BU of 1g5j by Molmil
COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD
Descriptor: APOPTOSIS REGULATOR BCL-X, BAD PROTEIN
Authors:Petros, A.M, Nettesheim, D.G, Wang, Y, Olejniczak, E.T, Meadows, R.P, Mack, J, Swift, K, Matayoshi, E.D, Zhang, H, Thompson, C.B, Fesik, S.W.
Deposit date:2000-11-01
Release date:2001-02-07
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.
Protein Sci., 9, 2000
1G5M
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BU of 1g5m by Molmil
HUMAN BCL-2, ISOFORM 1
Descriptor: PROTEIN (APOPTOSIS REGULATOR BCL-2 WITH PUTATIVE FLEXIBLE LOOP REPLACED WITH A PORTION OF APOPTOSIS REGULATOR BCL-X PROTEIN)
Authors:Petros, A.M, Medek, A, Nettesheim, D.G, Kim, D.H, Yoon, H.S, Swift, K, Matayoshi, E.D, Oltersdorf, T, Fesik, S.W.
Deposit date:2000-11-01
Release date:2001-03-21
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the antiapoptotic protein bcl-2.
Proc.Natl.Acad.Sci.USA, 98, 2001

220113

数据于2024-05-22公开中

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