8U27

Bcl-2-xL complexed with compound 35

Summary for 8U27

• Entry DOI: 10.2210/pdb8u27/pdb
• NMR Information: BMRB: 52100
• Descriptor: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate (2 entities in total)
• Functional Keywords: autophagy, apoptosis, selective inhibition
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 21199.52

Authors

Rizo, J.,Pan, Y.-Z. (deposition date: 2023-09-05, release date: 2023-09-13, Last modification date: 2023-11-08)

• Primary citation: Pan, Y.Z.,Liang, Q.,Tomchick, D.R.,De Brabander, J.K.,Rizo, J.; Structural insights for selective disruption of Beclin 1 binding to Bcl-2.; Commun Biol, 6:1080-1080, 2023; PubMed: 37875561; DOI: 10.1038/s42003-023-05467-w

Experimental method

SOLUTION NMR