PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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4QSY	SHP2 SH2 domain in complex with GAB1 peptide Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Gogl, G, Remenyi, A. Deposit date: 2014-07-06 Release date: 2015-07-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain Descriptor: Cytoplasmic protein NCK2 Authors: Ran, X, Song, J. Deposit date: 2005-03-14 Release date: 2005-03-29 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2014-04-06 Release date: 2014-06-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-10-27 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
4K44	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Hajicek, N, Sondek, J. Deposit date: 2013-04-11 Release date: 2013-06-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
4K45	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide Authors: Sondek, J, Hajicek, N. Deposit date: 2013-04-11 Release date: 2013-06-26 Last modified: 2014-01-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
8X2P	The Crystal Structure of LCK from Biortus. Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, TETRAETHYLENE GLYCOL, ... Authors: Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y. Deposit date: 2023-11-10 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The Crystal Structure of LCK from Biortus. To Be Published
3PQZ	Grb7 SH2 with peptide Descriptor: Growth factor receptor-bound protein 7, cyclic peptide Authors: Wilce, J.A. Deposit date: 2010-11-29 Release date: 2011-07-20 Last modified: 2011-09-21 Method: X-RAY DIFFRACTION (2.413 Å) Cite: Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3S8N	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S9K	Crystal structure of the Itk SH2 domain. Descriptor: CITRIC ACID, Tyrosine-protein kinase ITK/TSK Authors: Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. Deposit date: 2011-06-01 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.354 Å) Cite: Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
5GJI	PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex Descriptor: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ... Authors: Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. Deposit date: 2016-06-30 Release date: 2016-12-14 Last modified: 2017-05-10 Method: X-RAY DIFFRACTION (0.9 Å) Cite: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
5GJH	Gads SH2 domain/CD28-derived peptide complex Descriptor: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28 Authors: Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. Deposit date: 2016-06-30 Release date: 2016-12-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
3S8L	Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8O	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
5EEQ	Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor Descriptor: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION Authors: Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. Deposit date: 2015-10-23 Release date: 2016-06-15 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5EEL	Grb7 SH2 with bicyclic peptide inhibitor Descriptor: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... Authors: Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. Deposit date: 2015-10-23 Release date: 2016-06-15 Last modified: 2018-12-26 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3T04	Crystal structure of monobody 7c12/abl1 sh2 domain complex Descriptor: GLYCEROL, MONOBODY 7C12, SULFATE ION, ... Authors: Wojcik, J.B, Wyrzucki, A.M, Koide, S. Deposit date: 2011-07-19 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
3WA4	Grb2 SH2 domain/CD28-derived peptide complex Descriptor: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ... Authors: Higo, K, Oda, M, Ito, N. Deposit date: 2013-04-23 Release date: 2014-02-26 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28 Plos One, 8, 2013
3UYO	Crystal structure of monobody SH13/ABL1 SH2 domain complex Descriptor: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Koide, A, Koide, S. Deposit date: 2011-12-06 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
3US4	Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution Descriptor: Megakaryocyte-associated tyrosine-protein kinase, SULFATE ION Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-11-22 Release date: 2011-12-28 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution To be published
1SPS	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PEPTIDE YEEI, SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1SKJ	COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX Descriptor: 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN Authors: Holland, D.R, Rubin, J.R. Deposit date: 1997-09-18 Release date: 1998-02-25 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997

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