5GJI

PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex

Summary for 5GJI

• Entry DOI: 10.2210/pdb5gji/pdb
• Related: 5GJH
• Descriptor: Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28, SULFATE ION, ... (5 entities in total)
• Functional Keywords: antigens, phosphopeptides, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface : P10747
• Total number of polymer chains: 2
• Total formula weight: 13851.28

Authors

Inaba, S.,Numoto, N.,Morii, H.,Ogawa, S.,Ikura, T.,Abe, R.,Ito, N.,Oda, M. (deposition date: 2016-06-30, release date: 2016-12-14, Last modification date: 2017-05-10)

• Primary citation: Inaba, S.,Numoto, N.,Ogawa, S.,Morii, H.,Ikura, T.,Abe, R.,Ito, N.,Oda, M.; Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins; J. Biol. Chem., 292:1052-1060, 2017; PubMed: 27927989; DOI: 10.1074/jbc.M116.755173

Experimental method

X-RAY DIFFRACTION (0.9 Å)