5GJI
PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 108 | 12433.0 | 1 | UniProt (P27986) Pfam (PF00017) | Homo sapiens (Human) | PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
| 2 | B (B) | T-cell-specific surface glycoprotein CD28 | polymer | 8 | 1038.0 | 1 | UniProt (P10747) | Homo sapiens | TP44 |
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A: 325 - 430 (UniProt: P27986)
| PDB | External Database | Details |
|---|---|---|
| Gly 323 | - | expression tag |
| Ser 324 | - | expression tag |
| Asn 330 | Asp 330 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13471.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 380.3 | |
| All* | Total formula weight | 13851.3 |
