1SKJ

COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX

Summary for 1SKJ
DescriptorPP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID (3 entities in total)
Functional Keywordstyrosine-protein kinase, v-src sh2 domain, phosphotyrosine recognition domain, pp60 src sh2 domain, peptidomimetic, ureido
Biological sourceRous sarcoma virus
Total number of polymer chains1
Total formula weight13479.07
Authors
Holland, D.R.,Rubin, J.R. (deposition date: 1997-09-18, release date: 1998-02-25, Last modification date: 2011-07-13)
Primary citationFergus, J.H.,Holland, D.R.,Lunney, E.A.,Marks, J.S.,McConnell, P.,Mueller, W.T.,Plummer, M.S.,Sawyer, T.K.,Shahripour, A.
Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.
J.Med.Chem., 40:3719-3725, 1997
PubMed: 9371236
DOI: 110.1021/jm970402q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation
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PDB entries from 2021-06-16