PDB: 115 件ウェブページステータス検索Chemie searchBIRD

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6SJC	Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)adenosine 分子名称: 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, Aspartate--tRNA(Asp) ligase 著者 De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. 登録日 2019-08-13 公開日 2020-01-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
4J15	Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex 分子名称: Aspartate--tRNA ligase, cytoplasmic, GLYCEROL 著者 Kim, K.R, Park, S.H, Kim, H.S, Kim, B.-G, Kim, D.G, Rhee, K.H, Park, M.S, Kim, H.-J, Kim, S, Han, B.W. 登録日 2013-02-01 公開日 2013-05-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex Proteins, 81, 2013
5XIX	The canonical domain of human asparaginyl-tRNA synthetase 分子名称: Asparagine--tRNA ligase, cytoplasmic, GLYCEROL 著者 Park, J.S, Han, B.W. 登録日 2017-04-28 公開日 2018-05-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity. Int. J. Biol. Macromol., 120, 2018
6AQG	Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium ulcerans complexed with L-lysine and Cladosporin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, LYSINE, Lysine--tRNA ligase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-08-19 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium ulcerans complexed with L-lysine and Cladosporin to be published
1WYD	Crystal Structure of Aspartyl-tRNA synthetase from Sulfolobus tokodaii 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, SULFATE ION, ... 著者 Maeda, Y, Hossain, M.T, Ubukata, S, Suzuki, K, Sekiguchi, T, Takenaka, A. 登録日 2005-02-12 公開日 2006-07-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the nondiscriminating aspartyl-tRNA synthetase from the crenarchaeon Sulfolobus tokodaii strain 7 reveals the recognition mechanism for two different tRNA anticodons ACTA CRYSTALLOGR.,SECT.D, 63, 2007
1EOV	FREE ASPARTYL-TRNA SYNTHETASE (ASPRS) (E.C. 6.1.1.12) FROM YEAST 分子名称: ASPARTYL-TRNA SYNTHETASE 著者 Sauter, C, Lorber, B, Cavarelli, J, Moras, D, Giege, R. 登録日 2000-03-24 公開日 2000-09-24 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The free yeast aspartyl-tRNA synthetase differs from the tRNA(Asp)-complexed enzyme by structural changes in the catalytic site, hinge region, and anticodon-binding domain. J.Mol.Biol., 299, 2000
1N9W	Crystal structure of the non-discriminating and archaeal-type aspartyl-tRNA synthetase from Thermus thermophilus 分子名称: aspartyl-tRNA synthetase 2 著者 Charron, C, Roy, H, Blaise, M, Giege, R, Kern, D. 登録日 2002-11-26 公開日 2003-04-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Non-discriminating and discriminating aspartyl-tRNA synthetases differ in the anticodon-binding domain EMBO J., 22, 2003
3BJU	Crystal Structure of tetrameric form of human lysyl-tRNA synthetase 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ... 著者 Guo, M, Yang, X.L, Schimmel, P. 登録日 2007-12-04 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Proc.Natl.Acad.Sci.Usa, 105, 2008
1E24	LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM complexed with lysine and ATP and MN2+ 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, LYSINE, ... 著者 Desogus, G, Todone, F, Brick, P, Onesti, S. 登録日 2000-05-16 公開日 2000-07-28 最終更新日 2011-08-24 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
6AQH	Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium thermoresistibile complexed with L-lysine and Cladosporin 分子名称: 1,2-ETHANEDIOL, LYSINE, Lysine--tRNA ligase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-08-19 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium thermoresistibile complexed with L-lysine and Cladosporin to be published
6O3F	Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis with complexed with L-lysine and a difluoro cyclohexyl chromone ligand 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, LYSINE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-02-26 公開日 2019-03-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis with complexed with L-lysine and a difluoro cyclohexyl chromone ligand to be published
1E1T	LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM COMPLEXED WITH THE LYSYL_ADENYLATE INTERMEDIATE 分子名称: ADENOSINE-5'-[LYSYL-PHOSPHATE], GLYCEROL, LYSYL-TRNA SYNTHETASE, ... 著者 Desogus, G, Todone, F, Brick, P, Onesti, S. 登録日 2000-05-10 公開日 2000-07-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
1C0A	CRYSTAL STRUCTURE OF THE E. COLI ASPARTYL-TRNA SYNTHETASE : TRNAASP : ASPARTYL-ADENYLATE COMPLEX 分子名称: ADENOSINE MONOPHOSPHATE, ASPARTYL TRNA, ASPARTYL TRNA SYNTHETASE, ... 著者 Eiler, S, Dock-Bregeon, A.-C, Moulinier, L, Thierry, J.-C, Moras, D. 登録日 1999-07-15 公開日 1999-11-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Synthesis of aspartyl-tRNA(Asp) in Escherichia coli--a snapshot of the second step. EMBO J., 18, 1999
4RMF	Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target 分子名称: 2,2-bis(hydroxymethyl)propane-1,3-diol, Aspartate--tRNA(Asp/Asn) ligase, FORMIC ACID 著者 Cox, J.A.G, Gurcha, S.S, Veeraraghavan, U, Besra, G.S, Futterer, K. 登録日 2014-10-21 公開日 2014-11-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target. Plos One, 9, 2014
3NEN	Unliganded aspartyl-tRNA synthetase from thermococcus kodakarensis 分子名称: Aspartyl-tRNA synthetase 著者 Schmitt, E, Moras, D, Moulinier, L. 登録日 2010-06-09 公開日 2010-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation Embo J., 17, 1998
1G51	ASPARTYL TRNA SYNTHETASE FROM THERMUS THERMOPHILUS AT 2.4 A RESOLUTION 分子名称: ADENOSINE MONOPHOSPHATE, ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE, ASPARTYL-TRNA SYNTHETASE, ... 著者 Poterzsman, A, Delarue, M, Thierry, J.C, Moras, D. 登録日 2000-10-30 公開日 2000-12-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Synthesis and recognition of aspartyl-adenylate by Thermus thermophilus aspartyl-tRNA synthetase. J.Mol.Biol., 244, 1994
5ZG8	Crystal Structure of TtNRS 分子名称: Asparagine--tRNA ligase 著者 Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J. 登録日 2018-03-08 公開日 2019-03-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of TtNRS To be published
4EX5	Crystal structure of lysyl-tRNA synthetase LysRS from Burkholderia thailandensis bound to lysine 分子名称: LYSINE, Lysine--tRNA ligase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-04-29 公開日 2012-05-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms. Sci Rep, 7, 2017
1E22	LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM complexed with lysine and the non-hydrolysable atp analogue amp-pcp 分子名称: GLYCEROL, LYSINE, LYSYL-TRNA SYNTHETASE, ... 著者 Desogus, G, Todone, F, Brick, P, Onesti, S. 登録日 2000-05-15 公開日 2000-07-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
7BT5	Crystal structure of plasmodium LysRS complexing with an antitumor compound 分子名称: LYSINE, Lysine--tRNA ligase, N4-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N2-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine 著者 Zhou, J, Wang, J, Fang, P. 登録日 2020-03-31 公開日 2020-09-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.493 Å) 主引用文献 Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor. Nucleic Acids Res., 48, 2020
3A5Z	Crystal structure of Escherichia coli GenX in complex with elongation factor P 分子名称: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Elongation factor P, Putative lysyl-tRNA synthetase 著者 Sumida, T, Yanagisawa, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2009-08-17 公開日 2010-08-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat.Struct.Mol.Biol., 17, 2010
7EA9	Crystal Structure of human lysyl-tRNA synthetase Y145H mutant 分子名称: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, GLYCEROL, Lysine--tRNA ligase 著者 Wu, S, Hei, Z, Zheng, L, Zhou, J, Liu, Z, Wang, J, Fang, P. 登録日 2021-03-06 公開日 2021-03-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment. Biochem.Biophys.Res.Commun., 554, 2021
6CHD	Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine 分子名称: 1,2-ETHANEDIOL, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, GLYCEROL, ... 著者 Dranow, D.M, Abendroth, J, Lorimer, D.D. 登録日 2018-02-22 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine to be published
6ILH	Crystal Structure of human lysyl-tRNA synthetase L350H mutant 分子名称: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine-tRNA ligase 著者 Hei, Z, Liu, Z, Wang, J, Fang, P. 登録日 2018-10-18 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. J. Biol. Chem., 294, 2019
7QHN	CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM Mycobacterium tuberculosis COMPLEXED WITH L-LYSINE and an inhibitor 分子名称: 6-azanyl-2-cyclohexyl-4-fluoranyl-1~{H}-pyrrolo[3,4-c]pyridin-3-one, LYSINE, Lysine--tRNA ligase 1 著者 Dawson, A, Robinson, D.A, Tamjar, J, Wyatt, P, Green, S. 登録日 2021-12-13 公開日 2022-10-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs. Nat Commun, 13, 2022

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