7EA9

Crystal Structure of human lysyl-tRNA synthetase Y145H mutant

Summary for 7EA9

• Entry DOI: 10.2210/pdb7ea9/pdb
• Descriptor: Lysine--tRNA ligase, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, GLYCEROL, ... (4 entities in total)
• Functional Keywords: lysyl-trna synthetase, lysrs, disease related mutant, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 243411.45

Authors

Wu, S.,Hei, Z.,Zheng, L.,Zhou, J.,Liu, Z.,Wang, J.,Fang, P. (deposition date: 2021-03-06, release date: 2021-03-31, Last modification date: 2023-11-29)

• Primary citation: Wu, S.,Hei, Z.,Zheng, L.,Zhou, J.,Liu, Z.,Wang, J.,Fang, P.; Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment.; Biochem.Biophys.Res.Commun., 554:83-88, 2021; PubMed: 33784510; DOI: 10.1016/j.bbrc.2021.03.093

Experimental method

X-RAY DIFFRACTION (2.5 Å)