7BT5

Crystal structure of plasmodium LysRS complexing with an antitumor compound

Summary for 7BT5

• Entry DOI: 10.2210/pdb7bt5/pdb
• Descriptor: Lysine--tRNA ligase, LYSINE, N4-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N2-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: protein translation, lysyl-trna synthetase, ligase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 121018.15

Authors

Zhou, J.,Wang, J.,Fang, P. (deposition date: 2020-03-31, release date: 2020-09-30, Last modification date: 2023-11-29)

• Primary citation: Zhou, J.,Huang, Z.,Zheng, L.,Hei, Z.,Wang, Z.,Yu, B.,Jiang, L.,Wang, J.,Fang, P.; Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor.; Nucleic Acids Res., 48:11566-11576, 2020; PubMed: 33053158; DOI: 10.1093/nar/gkaa862

Experimental method

X-RAY DIFFRACTION (2.493 Å)