7BT5

Crystal structure of plasmodium LysRS complexing with an antitumor compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Lysine--tRNA ligase	polymer	516	59781.1	2	UniProt (W7F9C1) Pfam (PF01336) Pfam (PF00152) UniProt (by SIFTS) (Q8IDJ8) In PDB	Plasmodium falciparum	Lysyl-tRNA synthetase
2	A, B	LYSINE	non-polymer		147.2	2	Chemie (LYS)
3	A, B	N4-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N2-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine	non-polymer		580.7	2	Chemie (F6O)
4		water	water		18.0	133	Chemie (HOH)

Sequence modifications

A, B: 77 - 583 (UniProt: W7F9C1)

PDB	External Database	Details
Met 76	-	initiating methionine
Gly 584	-	expression tag
Gly 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag
His 590	-	expression tag
His 591	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	119562.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1455.9
All*	Total formula weight	121018.1

*Water molecules are not included.