7QHN

CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM Mycobacterium tuberculosis COMPLEXED WITH L-LYSINE and an inhibitor

Summary for 7QHN

• Entry DOI: 10.2210/pdb7qhn/pdb
• Related: 7QH8
• Descriptor: Lysine--tRNA ligase 1, LYSINE, 6-azanyl-2-cyclohexyl-4-fluoranyl-1~{H}-pyrrolo[3,4-c]pyridin-3-one, ... (4 entities in total)
• Functional Keywords: ligase, mycobacterium tuberculosis, atp binding
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 1
• Total formula weight: 58526.05

Authors

Dawson, A.,Robinson, D.A.,Tamjar, J.,Wyatt, P.,Green, S. (deposition date: 2021-12-13, release date: 2022-10-19, Last modification date: 2024-02-07)

• Primary citation: Green, S.R.,Davis, S.H.,Damerow, S.,Engelhart, C.A.,Mathieson, M.,Baragana, B.,Robinson, D.A.,Tamjar, J.,Dawson, A.,Tamaki, F.K.,Buchanan, K.I.,Post, J.,Dowers, K.,Shepherd, S.M.,Jansen, C.,Zuccotto, F.,Gilbert, I.H.,Epemolu, O.,Riley, J.,Stojanovski, L.,Osuna-Cabello, M.,Perez-Herran, E.,Rebollo, M.J.,Guijarro Lopez, L.,Casado Castro, P.,Camino, I.,Kim, H.C.,Bean, J.M.,Nahiyaan, N.,Rhee, K.Y.,Wang, Q.,Tan, V.Y.,Boshoff, H.I.M.,Converse, P.J.,Li, S.Y.,Chang, Y.S.,Fotouhi, N.,Upton, A.M.,Nuermberger, E.L.,Schnappinger, D.,Read, K.D.,Encinas, L.,Bates, R.H.,Wyatt, P.G.,Cleghorn, L.A.T.; Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.; Nat Commun, 13:5992-5992, 2022; PubMed: 36220877; DOI: 10.1038/s41467-022-33736-5

Experimental method

X-RAY DIFFRACTION (2.58 Å)