6CHD

Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine

Summary for 6CHD

• Entry DOI: 10.2210/pdb6chd/pdb
• Descriptor: Lysine--tRNA ligase, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: atp binding, aminoacylation, amino acid binding, atp adenylyltransferase activity, trna binding, ligase, transferase, structure-guided drug discovery consortium
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform Cytoplasmic: Cytoplasm, cytosol . Isoform Mitochondrial: Mitochondrion : Q15046
• Total number of polymer chains: 2
• Total formula weight: 138447.74

Authors

Dranow, D.M.,Abendroth, J.,Lorimer, D.D. (deposition date: 2018-02-22, release date: 2018-03-07, Last modification date: 2023-10-04)

• Primary citation: Dranow, D.M.,Abendroth, J.,Baragana, B.,Walpole, C.,Lorimer, D.D.; Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine; to be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)