6CHD
Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine
Summary for 6CHD
Entry DOI | 10.2210/pdb6chd/pdb |
Descriptor | Lysine--tRNA ligase, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, SULFATE ION, ... (6 entities in total) |
Functional Keywords | atp binding, aminoacylation, amino acid binding, atp adenylyltransferase activity, trna binding, ligase, transferase, structure-guided drug discovery consortium |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform Cytoplasmic: Cytoplasm, cytosol . Isoform Mitochondrial: Mitochondrion : Q15046 |
Total number of polymer chains | 2 |
Total formula weight | 138447.74 |
Authors | Dranow, D.M.,Abendroth, J.,Lorimer, D.D. (deposition date: 2018-02-22, release date: 2018-03-07, Last modification date: 2023-10-04) |
Primary citation | Dranow, D.M.,Abendroth, J.,Baragana, B.,Walpole, C.,Lorimer, D.D. Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine to be published, |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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