8FWV
| Structure of the amino-terminal domain of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and noncompetitive inhibitor perampanel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. | Deposit date: | 2023-01-23 | Release date: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Rep, 42, 2023
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8FWU
| Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I. | Deposit date: | 2023-01-23 | Release date: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Rep, 42, 2023
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8FPC
| Conformation 1 of the ligand binding domain (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | Descriptor: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | Authors: | Nakagawa, T. | Deposit date: | 2023-01-04 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FP4
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8FPH
| Conformation 2 of the ligand binding domain (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | Descriptor: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | Authors: | Nakagawa, T. | Deposit date: | 2023-01-04 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FP9
| GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | Descriptor: | CALCIUM ION, CHLORIDE ION, Glutamate receptor 2, ... | Authors: | Nakagawa, T. | Deposit date: | 2023-01-04 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.44 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FPL
| LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) | Descriptor: | 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione, CYCLOTHIAZIDE, Glutamate receptor 2 | Authors: | Nakagawa, T. | Deposit date: | 2023-01-04 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQF
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8FQ5
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8FPK
| LBD conformation 1 of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) | Descriptor: | 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione, CYCLOTHIAZIDE, Glutamate receptor 2 | Authors: | Nakagawa, T. | Deposit date: | 2023-01-04 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQG
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8FQ8
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8FPG
| GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) | Descriptor: | CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | Authors: | Nakagawa, T. | Deposit date: | 2023-01-04 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.32 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQE
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8FQ2
| LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) | Descriptor: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | Authors: | Nakagawa, T. | Deposit date: | 2023-01-05 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQD
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8FPS
| GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) | Descriptor: | CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | Authors: | Nakagawa, T. | Deposit date: | 2023-01-05 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.38 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQ6
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8FQB
| GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) | Descriptor: | CALCIUM ION, CHLORIDE ION, Glutamate receptor 2, ... | Authors: | Nakagawa, T. | Deposit date: | 2023-01-05 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.36 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FR0
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8FQ3
| LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) | Descriptor: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | Authors: | Nakagawa, T. | Deposit date: | 2023-01-05 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQH
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8FQ1
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8FPY
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8FPV
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