8FPH

Conformation 2 of the ligand binding domain (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg)

Summary for 8FPH

Entry DOI	10.2210/pdb8fph/pdb
EMDB information	29360 29361 29363 29364 29367 29368
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, CYCLOTHIAZIDE, ... (4 entities in total)
Functional Keywords	ionotropic glutamate receptors, ampa receptors, ion channel, ligand-gated ion channel, auxiliary subunit, stargazing, tarp gamma2, transport protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	4
Total formula weight	400385.87
Authors	Nakagawa, T. (deposition date: 2023-01-04, release date: 2024-02-28, Last modification date: 2024-03-13)
Primary citation	Nakagawa, T.,Wang, X.T.,Miguez-Cabello, F.J.,Bowie, D. The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38409505 DOI: 10.1038/s41594-024-01228-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.14 Å)

Structure validation