8FQ6
LBD of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150)
Summary for 8FQ6
Entry DOI | 10.2210/pdb8fq6/pdb |
EMDB information | 29373 29379 |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, CYCLOTHIAZIDE, ... (4 entities in total) |
Functional Keywords | inotropic glutamate receptors, ampa receptors, ligand gated ion channel, auxiliary subunit, tarp, stargazin, tarp gamma2, glutamate, calcium, neurotransmitter receptor, synaptic transmission, transport protein |
Biological source | Rattus norvegicus (Norway rat) |
Total number of polymer chains | 4 |
Total formula weight | 400385.87 |
Authors | Nakagawa, T. (deposition date: 2023-01-05, release date: 2024-02-28, Last modification date: 2024-05-01) |
Primary citation | Nakagawa, T.,Wang, X.T.,Miguez-Cabello, F.J.,Bowie, D. The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31:688-700, 2024 Cited by PubMed: 38409505DOI: 10.1038/s41594-024-01228-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.14 Å) |
Structure validation
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