8FQ6
LBD of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (B, C, D, A) | Glutamate receptor 2 | polymer | 889 | 99559.5 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | E, G, I, K (B, C, D, A) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
| 3 | F, H, J, L (B, C, D, A) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) | |||
| 4 | M, N, O, P (B, C, D, A) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
B, C, D, A: -20 - 868 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Asp 848 | - | insertion |
| Tyr 849 | - | insertion |
| Lys 850 | - | insertion |
| Asp 851 | - | insertion |
| Asp 852 | - | insertion |
| Asp 853 | - | insertion |
| Asp 854 | Tyr 869 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 398237.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2148.0 | |
| All* | Total formula weight | 400385.9 |
