8FWU

Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX

Summary for 8FWU

Entry DOI	10.2210/pdb8fwu/pdb
EMDB information	29519
Descriptor	Glutamate receptor ionotropic, kainate 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	iglur, kainate receptor, positive allosteric modulator, dnqx, membrane protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	4
Total formula weight	428062.91
Authors	Yen, L.Y.,Gangwar, S.P.,Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2023-01-23, release date: 2023-04-19)
Primary citation	Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Rep, 42:112124-112124, 2023 Cited by PubMed: 36857176 DOI: 10.1016/j.celrep.2023.112124 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.18 Å)

Structure validation