8FQE

LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10)

Summary for 8FQE

Entry DOI	10.2210/pdb8fqe/pdb
EMDB information	29382 29385
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, CYCLOTHIAZIDE, ... (4 entities in total)
Functional Keywords	inotropic glutamate receptors, ampa receptors, ligand gated ion channel, auxiliary subunit, tarp, stargazin, tarp gamma2, glutamate, calcium, neurotransmitter receptor, synaptic transmission, transport protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	4
Total formula weight	397567.44
Authors	Nakagawa, T. (deposition date: 2023-01-06, release date: 2024-02-28, Last modification date: 2024-05-01)
Primary citation	Nakagawa, T.,Wang, X.T.,Miguez-Cabello, F.J.,Bowie, D. The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31:688-700, 2024 Cited by PubMed: 38409505 DOI: 10.1038/s41594-024-01228-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.14 Å)

Structure validation