2DRD
 
 | | Crystal structure of a multidrug transporter reveal a functionally rotating mechanism | | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ACRB | | Authors: | Murakami, S, Nakashima, R, Yamashita, E, Matsumoto, T. | | Deposit date: | 2006-06-08 | | Release date: | 2006-08-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Nature, 443, 2006
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2DR6
 | | Crystal structure of a multidrug transporter reveal a functionally rotating mechanism | | Descriptor: | ACRB, DOXORUBICIN | | Authors: | Murakami, S, Nakashima, R, Yamashita, E, Matsumoto, T. | | Deposit date: | 2006-06-08 | | Release date: | 2006-08-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Nature, 443, 2006
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2DHH
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5JMN
 | | Fusidic acid bound AcrB | | Descriptor: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, DARPin, ... | | Authors: | Oswald, C, Tam, H.K, Pos, K.M. | | Deposit date: | 2016-04-29 | | Release date: | 2016-12-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB.
Nat Commun, 7, 2016
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5KPD
 | | Mouse pgp 34 linker deleted double EQ mutant | | Descriptor: | Multidrug resistance protein 1A | | Authors: | Xia, D, Esser, L, Zhou, F. | | Deposit date: | 2016-07-03 | | Release date: | 2016-11-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
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5KPI
 | | Mouse native PGP | | Descriptor: | Multidrug resistance protein 1A | | Authors: | Xia, D, Esser, L, Zhou, F. | | Deposit date: | 2016-07-04 | | Release date: | 2016-11-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (4.01 Å) | | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
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5KPJ
 | | Mouse pgp methylated protein | | Descriptor: | Multidrug resistance protein 1A | | Authors: | Xia, D, Esser, L, Zhou, F. | | Deposit date: | 2016-07-04 | | Release date: | 2016-11-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
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8BWR
 | | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with prostaglandin E2) | | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, ATP-binding cassette sub-family C member 4 | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-12-07 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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8BJF
 | | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (inward-facing conformation) | | Descriptor: | ATP-binding cassette sub-family C member 4, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-11-04 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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8BWQ
 | | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with topotecan) | | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ATP-binding cassette sub-family C member 4 | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-12-07 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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8BWP
 | | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with methotrexate) | | Descriptor: | ATP-binding cassette sub-family C member 4, METHOTREXATE | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-12-07 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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8BWO
 | | Cryo-EM structure of nanodisc-reconstituted human MRP4 with E1202Q mutation (outward-facing occluded conformation) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, MAGNESIUM ION | | Authors: | Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. | | Deposit date: | 2022-12-07 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4.
Structure, 31, 2023
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6T1Z
 | | LmrP from L. lactis, in an outward-open conformation, bound to Hoechst 33342 | | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DODECYL-ALPHA-D-MALTOSIDE, ... | | Authors: | Hutchin, A, Debruycker, V, Masureel, M, Legrand, P, Remaut, H, Govaerts, C. | | Deposit date: | 2019-10-07 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity.
Nat.Struct.Mol.Biol., 27, 2020
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3B5D
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3B61
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3B62
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2HYD
 | | Multidrug ABC transporter SAV1866 | | Descriptor: | ABC transporter homolog, ADENOSINE-5'-DIPHOSPHATE, SODIUM ION | | Authors: | Dawson, R.J.P, Locher, K.P. | | Deposit date: | 2006-08-05 | | Release date: | 2006-09-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of a bacterial multidrug ABC transporter.
Nature, 443, 2006
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5KO2
 | | Mouse pgp 34 linker deleted mutant Hg derivative | | Descriptor: | MERCURY (II) ION, Multidrug resistance protein 1A | | Authors: | Xia, D, Esser, L, Zhou, F. | | Deposit date: | 2016-06-29 | | Release date: | 2016-11-30 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
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5KOY
 | | Mouse pgp 34 linker deleted bound with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Multidrug resistance protein 1A | | Authors: | Xia, D, Esser, L, Zhou, F. | | Deposit date: | 2016-07-01 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.85 Å) | | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
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5NIV
 | | Crystal structure of 5D3 Fab | | Descriptor: | Heavy chain of 5D3 Fab, Light chain of 5D3 Fab | | Authors: | Manolaridis, I, Locher, K.P. | | Deposit date: | 2017-03-27 | | Release date: | 2017-06-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.498 Å) | | Cite: | Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
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8BHT
 | | ABCG2 turnover-1 state with tariquidar bound | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | | Authors: | Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. | | Deposit date: | 2022-10-31 | | Release date: | 2023-01-11 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8BI0
 | | ABCG2 turnover-2 state with tariquidar bound | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | | Authors: | Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. | | Deposit date: | 2022-11-01 | | Release date: | 2023-01-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7A69
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7A6F
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7A65
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