2DRD

Crystal structure of a multidrug transporter reveal a functionally rotating mechanism

Summary for 2DRD

Entry DOI	10.2210/pdb2drd/pdb
Related	2DHH 2DR6
Descriptor	ACRB, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE (2 entities in total)
Functional Keywords	membrane transporter, membrane protein, multidrug efflux, drug resistance, transporter, exporter, antiporter
Biological source	Escherichia coli
Cellular location	Cell inner membrane; Multi-pass membrane protein: P31224
Total number of polymer chains	3
Total formula weight	343110.70
Authors	Murakami, S.,Nakashima, R.,Yamashita, E.,Matsumoto, T. (deposition date: 2006-06-08, release date: 2006-08-22, Last modification date: 2024-03-13)
Primary citation	Murakami, S.,Nakashima, R.,Yamashita, E.,Matsumoto, T.,Yamaguchi, A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism Nature, 443:173-179, 2006 Cited by PubMed: 16915237 DOI: 10.1038/nature05076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation