Crystal structure of a multidrug transporter reveal a functionally rotating mechanism

Summary for 2DHH

Related2DR6 2DRD
DescriptorACRB (2 entities in total)
Functional Keywordsmembrane transporter, membrane protein, multidrug efflux, drug resistance, transporter, exporter, antiporter
Biological sourceEscherichia coli
Cellular locationCell inner membrane; Multi-pass membrane protein P31224
Total number of polymer chains3
Total molecular weight342653.23
Murakami, S.,Nakashima, R.,Yamashita, E.,Matsumoto, T. (deposition date: 2006-03-23, release date: 2006-08-22, Last modification date: 2011-07-13)
Primary citation
Murakami, S.,Nakashima, R.,Yamashita, E.,Matsumoto, T.,Yamaguchi, A.
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Nature, 443:173-179, 2006
PubMed: 16915237 (PDB entries with the same primary citation)
DOI: 10.1038/nature05076
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.3077614.8%18.2%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report